Comparison of heparin assay monitoring protocols (CHAMP): study protocol for a pragmatic randomised trial
Grace Van Winkle, Benjamin Tillman, Leena Choi, Sarah Berardi, Mary L Dear, Ariel Lewis, Todd W Rice · 2026
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Description
Grace Van Winkle and six colleagues describe the CHAMP trial, a pragmatic randomised study at Vanderbilt University Medical Center. The trial compares two ways to monitor intravenous heparin, a widely used blood thinner whose effects vary sharply between patients. One protocol adjusts the dose by the aPTT clotting test; the other uses an anti-Xa assay. The two have never been tested head to head in a prospective trial.
Running inside the hospital's learning health system from June 2024, the trial randomises inpatients who need heparin infusions to one monitoring protocol or the other. Outcomes will show which approach keeps levels in range more reliably. The authors designed the study to answer a daily dosing question with ordinary ward data.
Catalog record
| CREATOR | Grace Van Winkle, Benjamin Tillman, Leena Choi, Sarah Berardi, Mary L Dear, Ariel Lewis, Todd W Rice |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |