Effects of ursodeoxycholic acid on statin-induced impaired glucose tolerance: study protocol for a randomized controlled trial
Yue Yu, Jie Zheng, Jianqing She, Zuyi Yuan, Yue Wu · 2026
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Description
Yue Yu, Jie Zheng, Jianqing She, Zuyi Yuan and Yue Wu lay out, in a 2026 protocol, a randomised trial. It tests whether a liver-protective bile acid can stop statins from disturbing blood sugar. Statins raise the risk of new diabetes just enough to scare some patients off them, and ursodeoxycholic acid has hinted at glucose benefits without a prospective test.
One hundred twenty-eight adults will take part. All have newly diagnosed high cholesterol, no diabetes and no prior cardiovascular events. Each receives atorvastatin plus either the bile acid or a matching placebo. The treatment lasts one hundred eighty days, under double-blind conditions. The main outcome is the change in glycated haemoglobin, the standard long-term sugar marker. Body composition, metabolic risk factors and safety complete the outcome set.
Catalog record
| CREATOR | Yue Yu, Jie Zheng, Jianqing She, Zuyi Yuan, Yue Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |