Dietary Protein Reduction During Isocaloric Conditions Reduces Body Weight in Men With Overweight or Obesity
Aslak E Lyster, Amalie S Frederiksen, Jacob K Jensen, Annemarie Lundsgaard, Nicoline R Andersen, Kasper S Jørgensen, Daniela Weber, Lukas Nachtigall, Erik A Richter, Andreas M Fritzen, Bente Kiens · 2026
Read Dietary Protein Reduction During Isocaloric Conditions Reduces Body Weight in Men With Overweight or Obesity by Aslak E Lyster, Amalie S Frederiksen, Jacob K Jensen, Annemarie Lundsgaard, Nicoline R Andersen, Kasper S Jørgensen, Daniela Weber, Lukas Nachtigall, Erik A Richter, Andreas M Fritzen, Bente Kiens (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13422661.txt.
Description
Aslak E Lyster leads an eleven-author team testing, in a 2026 trial, whether eating less protein — without eating fewer calories — can itself slim men with overweight or obesity. In lean men, protein reduction raises the hormone FGF21 and energy needs; whether that translates into weight loss at stable calories was unknown.
Seventeen men spent five weeks on tightly controlled diets holding calories equal: protein at under half the habitual level, swapped for carbohydrate, versus normal protein. The low-protein group lost about two kilograms, and their FGF21 rose, with bigger hormone rises tracking bigger weight losses. Fat mass fell significantly while lean mass only tended downward. Muscle energy machinery and fat-tissue FGF21 signalling stayed unchanged, leaving the mechanism partly mysterious.
Catalog record
| CREATOR | Aslak E Lyster, Amalie S Frederiksen, Jacob K Jensen, Annemarie Lundsgaard, Nicoline R Andersen, Kasper S Jørgensen, Daniela Weber, Lukas Nachtigall, Erik A Richter, Andreas M Fritzen, Bente Kiens |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47634 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |