Viperin suppresses goose astrovirus type 2 replication through inhibition of viral RdRP activity
Haoran Xu, Jinhang Gao, Junjie Yang, Wenwen Cheng, Yan Cheng, Yingjun Lv · 2026
Read Viperin suppresses goose astrovirus type 2 replication through inhibition of viral RdRP activity by Haoran Xu, Jinhang Gao, Junjie Yang, Wenwen Cheng, Yan Cheng, Yingjun Lv (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13422359.txt.
Description
Xu and co-authors identify an antiviral defender in this 2026 study of goose astrovirus type 2. The pathogen causes fatal visceral gout in goslings just 3 to 15 days old. It has resisted control since emerging in 2018. They focused on viperin, an immune protein switched on by infection, and tested whether it genuinely restricts this virus.
Infection raised viperin levels in cells and in live birds, and experiments that boosted or silenced the protein confirmed it suppresses viral replication without blocking the virus from entering cells. Viperin's chemical engine room, its SAM domain, produces a molecule called ddhCTP that jams the virus's RNA-copying polymerase. Injecting goslings with ddhCTP itself reduced deaths, lowered viral loads, and lessened damage in kidney, spleen, and liver. The authors nominate both viperin and its product as antiviral leads for the poultry industry.
Catalog record
| CREATOR | Haoran Xu, Jinhang Gao, Junjie Yang, Wenwen Cheng, Yan Cheng, Yingjun Lv |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| LICENSE | https://creativecommons.org/publicdomain/zero/1.0 |
| RIGHTS | CC0 |
| SOURCE | Europe PMC |