Role of SCF/c-KIT axis in pericyte TNT-guided vessel branching
Daniela Virgintino, Antonio d’Amati, Tiziana Annese, Michelina De Giorgis, Antonella Bizzoca, Ignazio de Trizio, Thomas Wälchli, Marianna Sgarlata, Ramani Ramchandran, Roberto Perris, Francesco Girolamo, Mariella Errede · 2026
Read Role of SCF/c-KIT axis in pericyte TNT-guided vessel branching by Daniela Virgintino, Antonio d’Amati, Tiziana Annese, Michelina De Giorgis, Antonella Bizzoca, Ignazio de Trizio, Thomas Wälchli, Marianna Sgarlata, Ramani Ramchandran, Roberto Perris, Francesco Girolamo, Mariella Errede (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13422300.txt.
Description
Daniela Virgintino leads a twelve-author team studying, in a 2026 paper, how the smallest brain vessels sprout branches with help from support cells. In the developing human forebrain, pericytes at the growing front extend hair-thin tunnels called tunnelling nanotubes. These tunnels bridge toward other vessels. The team asked whether the SCF signal and its c-KIT receptor steer this partnership.
High-resolution confocal microscopy and three-dimensional modelling of developing brain and glioblastoma tissue located both molecules. The nanotubes, marked by the protein NG2, were counted across healthy and tumour vascular networks, and double staining with an endothelial marker fixed each signal's cellular home. The authors read the pattern as a non-canonical route of vessel-pericyte communication worth targeting in tumours.
Catalog record
| CREATOR | Daniela Virgintino, Antonio d’Amati, Tiziana Annese, Michelina De Giorgis, Antonella Bizzoca, Ignazio de Trizio, Thomas Wälchli, Marianna Sgarlata, Ramani Ramchandran, Roberto Perris, Francesco Girolamo, Mariella Errede |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48852 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |