Dual functional genomics reveals a broad and convergent landscape of asciminib resistance in BCR::ABL1
Ivan Sokirniy, Zeyu Yang, Justin Pritchard · 2026
Read Dual functional genomics reveals a broad and convergent landscape of asciminib resistance in BCR::ABL1 by Ivan Sokirniy, Zeyu Yang, Justin Pritchard (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13422289.txt.
Description
Ivan Sokirniy, Zeyu Yang and Justin Pritchard map, in a 2026 study, every escape route leukaemia cells find against the drug asciminib. The drug treats chronic myeloid leukaemia by gripping a side pocket on the BCR::ABL1 fusion protein. It dodges resistance to older drugs. Yet new resistance mutations keep appearing, and the full map was unknown.
Their two-stage genomics first scanned the whole protein with a base-editing screen to find resistance hotspots, then tested every possible amino-acid change inside them. A further screen layered mutations onto cells already carrying a classic resistance change, exposing interactions between mutations. The screens found 279 resistance changes spread broadly across the protein. A fluorescent sensor measured the protein's shape in living cells to connect form with drug response.
Catalog record
| CREATOR | Ivan Sokirniy, Zeyu Yang, Justin Pritchard |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 78524 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |