HIF-1α attenuates ferroptosis-associated dermal fibroblast senescence via modulation of NF-κB–DPP4 signaling
Shang-Chuan Ng, Shih-Wen Kao, Chih‑Jung Chen, Shinn-Zong Lin, Dennis Jine-Yuan Hsieh, Chia-Hua Kuo, Kuan-Ho Lin, Chih-Yang Huang, Wei-Wen Kuo · 2026
Read HIF-1α attenuates ferroptosis-associated dermal fibroblast senescence via modulation of NF-κB–DPP4 signaling by Shang-Chuan Ng, Shih-Wen Kao, Chih‑Jung Chen, Shinn-Zong Lin, Dennis Jine-Yuan Hsieh, Chia-Hua Kuo, Kuan-Ho Lin, Chih-Yang Huang, Wei-Wen Kuo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13422273.txt.
Description
Shang-Chuan Ng leads a nine-author team probing, in a 2026 study, whether a low-oxygen sensor protein can slow skin cell ageing driven by an iron-linked death process. Skin ageing involves chronic oxidative stress, and ferroptosis — cell death fuelled by iron and fat oxidation — has been tied to a surface protein called DPP4 in the ageing programme.
The oxygen sensor HIF-1α proved scarce in aged human skin fibroblasts and sun-aged skin, and removing it sped senescence. Gene profiling hinted that low oxygen damps ferroptosis pathways. Drug experiments in cells tested each link of the proposed chain through the NF-κB regulator to DPP4. Aged mice treated with an HIF-1α activator or a ferroptosis blocker checked the idea in living skin.
Catalog record
| CREATOR | Shang-Chuan Ng, Shih-Wen Kao, Chih‑Jung Chen, Shinn-Zong Lin, Dennis Jine-Yuan Hsieh, Chia-Hua Kuo, Kuan-Ho Lin, Chih-Yang Huang, Wei-Wen Kuo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73507 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |