Environmental enrichment mitigates sevoflurane-induced neurodevelopmental injury via cGAS–STING–dependent microglial modulation
Feixiang Li, Bingqing Gong, Haiyan Wu, Yongyan Yang, Ying Luo, Yonghao Yu, Ding Li · 2026
Read Environmental enrichment mitigates sevoflurane-induced neurodevelopmental injury via cGAS–STING–dependent microglial modulation by Feixiang Li, Bingqing Gong, Haiyan Wu, Yongyan Yang, Ying Luo, Yonghao Yu, Ding Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13422118.txt.
Description
Feixiang Li and six colleagues explore, in a 2026 study, an unexpected shield against anaesthetic harm to the newborn brain: a rich environment. The gas sevoflurane, given to infant mice, left lasting learning problems, and the team traced the injury through the brain's immune cells, the microglia, which pruned too many synapses.
The chain ran from damaged mitochondria leaking DNA into the cell, which tripped a sensor pathway called cGAS-STING that fired up the microglia. Mice raised in enriched surroundings — more space, toys and social contact — kept healthier mitochondria, quieter sensors and better cognition. Impoverished housing did the opposite, deepening injury. The authors argue that early environment tunes vulnerability to anaesthesia.
Catalog record
| CREATOR | Feixiang Li, Bingqing Gong, Haiyan Wu, Yongyan Yang, Ying Luo, Yonghao Yu, Ding Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39116 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |