Targeting oxidative stress-NLRP3-apoptotic-steroidogenic axis in doxorubicin-induced testicular toxicity: protective efficacy of ferulic acid niosomes
Mahran Mohamed Abd El-Emam, Aya Elhady Atia, Mona A. Bakry, Rabab A. Husseini, Eman Elrefaei, Noha Osama El-Shaer, Safaa I. Khater, Ola Ali, Ahmed El-Sayed Yousef, Hussein I. Elbelbesy · 2026
Read Targeting oxidative stress-NLRP3-apoptotic-steroidogenic axis in doxorubicin-induced testicular toxicity: protective efficacy of ferulic acid niosomes by Mahran Mohamed Abd El-Emam, Aya Elhady Atia, Mona A. Bakry, Rabab A. Husseini, Eman Elrefaei, Noha Osama El-Shaer, Safaa I. Khater, Ola Ali, Ahmed El-Sayed Yousef, Hussein I. Elbelbesy (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13422117.txt.
Description
Mahran Mohamed Abd El-Emam leads a ten-author team testing, in a 2026 study, whether packaging a plant antioxidant into tiny carriers protects rat testes from chemotherapy damage. Doxorubicin is a widely used cancer drug whose usefulness is capped by harm to fast-dividing organs, and the testis is a prime casualty.
Forty male rats were split into four groups: saline, drug alone, drug plus free ferulic acid, and drug plus the acid loaded into niosome bubbles. The drug alone wrecked hormone levels, antioxidant defences and tissue structure while switching on inflammation and cell-death programmes and silencing sperm-production genes. Free acid softened the damage. The niosome version did better still, restoring hormones and tissue architecture most completely.
Catalog record
| CREATOR | Mahran Mohamed Abd El-Emam, Aya Elhady Atia, Mona A. Bakry, Rabab A. Husseini, Eman Elrefaei, Noha Osama El-Shaer, Safaa I. Khater, Ola Ali, Ahmed El-Sayed Yousef, Hussein I. Elbelbesy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| LICENSE | https://creativecommons.org/publicdomain/zero/1.0 |
| RIGHTS | CC0 |
| SOURCE | Europe PMC |