Endostatin, chronic kidney disease (CKD) and anemia among older people: a secondary analysis of the screening for CKD among older people across Europe (SCOPE) study
Andrea Corsonello, Luca Soraci, Johan Ärnlöv, Axel C. Carlsson, Tobias Rudholm Feldreich, Anders Larsson, Regina Roller-Wirnsberger, Gerhard Wirnsberger, Francesco Mattace-Raso, Lisanne Tap, Francesc Formiga, Rafael Moreno-González, Tomasz Kostka, Agnieszka Guligowska, Ronit Ben-Romano, Itshak Melzer, Christian Weingart, Robert Kob, Cornel C. Sieber, Lucia Muglia, Fabrizia Lattanzio, the SCOPE study investigators · 2026
Read Endostatin, chronic kidney disease (CKD) and anemia among older people: a secondary analysis of the screening for CKD among older people across Europe (SCOPE) study by Andrea Corsonello, Luca Soraci, Johan Ärnlöv, Axel C. Carlsson, Tobias Rudholm Feldreich, Anders Larsson, Regina Roller-Wirnsberger, Gerhard Wirnsberger, Francesco Mattace-Raso, Lisanne Tap, Francesc Formiga, Rafael Moreno-González, Tomasz Kostka, Agnieszka Guligowska, Ronit Ben-Romano, Itshak Melzer, Christian Weingart, Robert Kob, Cornel C. Sieber, Lucia Muglia, Fabrizia Lattanzio, the SCOPE study investigators (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13422087.txt.
Description
Andrea Corsonello leads a large European team examining, in a 2026 secondary analysis, whether a blood protein called endostatin helps explain anaemia in older people with kidney disease. Anaemia is common and draining in chronic kidney disease, and endostatin — a vessel-suppressing fragment that rises as kidneys fail — might blunt red blood cell production.
The SCOPE cohort contributed 2,008 participants aged seventy-five and over. At entry, about twenty percent were anaemic, and higher endostatin tracked with lower haemoglobin after extensive adjustment. Among 1,394 initially non-anaemic participants followed for two years, the analysis modelled new anaemia with death handled as a competing event. Kidney function was tested as a modifier of the relationship. The authors present endostatin as a candidate contributor to anaemia's origins.
Catalog record
| CREATOR | Andrea Corsonello, Luca Soraci, Johan Ärnlöv, Axel C. Carlsson, Tobias Rudholm Feldreich, Anders Larsson, Regina Roller-Wirnsberger, Gerhard Wirnsberger, Francesco Mattace-Raso, Lisanne Tap, Francesc Formiga, Rafael Moreno-González, Tomasz Kostka, Agnieszka Guligowska, Ronit Ben-Romano, Itshak Melzer, Christian Weingart, Robert Kob, Cornel C. Sieber, Lucia Muglia, Fabrizia Lattanzio, the SCOPE study investigators |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48782 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |