Population Pharmacokinetics and Pharmacodynamics of Depemokimab in People with Asthma and Chronic Rhinosinusitis with Nasal Polyps
Anders Thorsted, Lénaïg Tanneau, Alexandra Lavalley‐Morelle, Richard Follows, Loretta Jacques, Nicholas Bird, Philippe Gevaert, Ian Pavord, Jakob Ribbing, Anubha Gupta, Peter Howarth, Stein Schalkwijk · 2026
Read Population Pharmacokinetics and Pharmacodynamics of Depemokimab in People with Asthma and Chronic Rhinosinusitis with Nasal Polyps by Anders Thorsted, Lénaïg Tanneau, Alexandra Lavalley‐Morelle, Richard Follows, Loretta Jacques, Nicholas Bird, Philippe Gevaert, Ian Pavord, Jakob Ribbing, Anubha Gupta, Peter Howarth, Stein Schalkwijk (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13422010.txt.
Description
Anders Thorsted and co-authors model how depemokimab, an ultra-long-acting antibody drug, moves through the body and lowers blood eosinophils in asthma and chronic sinus disease with nasal polyps. The drug targets interleukin-5 and is designed for twice-yearly dosing. Their 2026 analysis pools data from three early-phase and four phase III trials.
The pharmacokinetic analysis included 961 participants and the combined analysis 1,324 participants. The model predicted a half-life of 47 days with negligible build-up between doses. A single 100 milligram dose cut blood eosinophil counts to under a quarter of baseline, and levels stayed suppressed across the 26-week dosing interval, with a small rise at the end. No patient factors required dose adjustment. The authors conclude the modelling supports twice-yearly 100 milligram dosing.
Catalog record
| CREATOR | Anders Thorsted, Lénaïg Tanneau, Alexandra Lavalley‐Morelle, Richard Follows, Loretta Jacques, Nicholas Bird, Philippe Gevaert, Ian Pavord, Jakob Ribbing, Anubha Gupta, Peter Howarth, Stein Schalkwijk |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |