IRES-like element-mediated translation of vsp1S4(-) suppresses BmCPV replication via RNAi antagonism
Xialing Chen, Qian Teng, Haoni Xue, Lixuan Li, Xiaoyan Du, Min Zhu, Xing Zhang, Chengliang Gong, Xiaolong Hu · 2026
Read IRES-like element-mediated translation of vsp1S4(-) suppresses BmCPV replication via RNAi antagonism by Xialing Chen, Qian Teng, Haoni Xue, Lixuan Li, Xiaoyan Du, Min Zhu, Xing Zhang, Chengliang Gong, Xiaolong Hu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13421769.txt.
Description
Xialing Chen and eight colleagues uncover, in a 2026 study, a tiny protein hidden on the 'wrong' strand of a silkworm virus genome. Double-stranded RNA viruses were assumed to make proteins only from their sense strand, leaving the antisense strand as a mere template for copying.
Ribosome profiling and protein analysis revealed a 78-amino-acid microprotein read from the antisense strand via an internal entry element resembling those viruses use to hijack ribosomes. The protein settles in the cell membrane and restrains viral replication. It grabs the virus's own silencer of the host's RNA interference defence. It then breaks that silencer's partnership with a key host protein, reviving the defence. The authors propose antisense microproteins as antiviral targets.
Catalog record
| CREATOR | Xialing Chen, Qian Teng, Haoni Xue, Lixuan Li, Xiaoyan Du, Min Zhu, Xing Zhang, Chengliang Gong, Xiaolong Hu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61684 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |