Refining a preclinical model of viral myocarditis in accordance with biotech standards
Jonas Stewen, Julia Riedesel, Juliane Stein, Brandon H Greene, Svenja Rohde, Sonja Suess, Bjoern Keiner, Priya Panjwani, Padmapriya Ponnuswamy, Juan E Camacho Londoño · 2026
Read Refining a preclinical model of viral myocarditis in accordance with biotech standards by Jonas Stewen, Julia Riedesel, Juliane Stein, Brandon H Greene, Svenja Rohde, Sonja Suess, Bjoern Keiner, Priya Panjwani, Padmapriya Ponnuswamy, Juan E Camacho Londoño (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13421655.txt.
Description
Stewen and co-authors refine a mouse model of viral myocarditis in this 2026 study, aiming for better science with less animal suffering. Heart inflammation from coxsackievirus B3 can progress to heart failure in people. But the standard mouse model also wrecks the pancreas. That confounds results and adds burden. So the team combined a gentler diet with advanced imaging.
Infected mice fed a hydrolyzed amino acid diet lost less weight and kept steadier blood sugar while still developing cardiac inflammation and scarring. Four-dimensional ultrasound with strain analysis detected pumping dysfunction sensitively and reproducibly, flagging early regional damage that mirrors clinical myocarditis. Tissue analysis confirmed inflammation peaking at day seven after infection and abnormalities persisting through day 56 of monitoring. The authors present the refined model as a more ethical, translationally faithful platform for testing therapies.
Catalog record
| CREATOR | Jonas Stewen, Julia Riedesel, Juliane Stein, Brandon H Greene, Svenja Rohde, Sonja Suess, Bjoern Keiner, Priya Panjwani, Padmapriya Ponnuswamy, Juan E Camacho Londoño |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |