Submicron traction-force mapping reveals mitochondrial regulation of nanoscale force coordination during rigidity sensing under oxidative stress
Muhammad Anwar Ul Hassan, Seok Gi Kim, Dan Bi Im, Jung Seung Lee, Gwang Lee, Sungsu Park · 2026
Read Submicron traction-force mapping reveals mitochondrial regulation of nanoscale force coordination during rigidity sensing under oxidative stress by Muhammad Anwar Ul Hassan, Seok Gi Kim, Dan Bi Im, Jung Seung Lee, Gwang Lee, Sungsu Park (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13421567.txt.
Description
Muhammad Anwar Ul Hassan and five colleagues map, in a 2026 study, the tiny forces cells use to feel how stiff their surroundings are, and show that oxidative stress scrambles that sense. Cells on flexible micropillars bend them as they pull, letting the team read traction forces at submicron scale during spreading.
Mouse fibroblasts exposed to a sublethal dose of hydrogen peroxide failed to remodel their skeletons and adhesions normally on stiff surfaces, and their nanoscale force units lost coordination. Their mitochondrial networks fragmented, with matching shifts in dynamics genes. Cells genetically lacking a mitochondrial fusion protein copied the defect exactly. The authors name mitochondrial integrity as a key control on stiffness sensing under stress.
Catalog record
| CREATOR | Muhammad Anwar Ul Hassan, Seok Gi Kim, Dan Bi Im, Jung Seung Lee, Gwang Lee, Sungsu Park |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |