An improved analytic workflow for serum mtDNA DAMP abundance, fragmentation and heteroplasmic variants: a retrospective analysis of acute respiratory failure patients
Grant T. Daly, Emily M. Hartsell, Viktor M. Pastukh, Justin T. Roberts, Adeyeye I. Haastrup, Lina D. Purcell, Madhuri S. Mulekar, D. Clark Files, Peter E. Morris, Mark N. Gillespie, Raymond J. Langley · 2026
Read An improved analytic workflow for serum mtDNA DAMP abundance, fragmentation and heteroplasmic variants: a retrospective analysis of acute respiratory failure patients by Grant T. Daly, Emily M. Hartsell, Viktor M. Pastukh, Justin T. Roberts, Adeyeye I. Haastrup, Lina D. Purcell, Madhuri S. Mulekar, D. Clark Files, Peter E. Morris, Mark N. Gillespie, Raymond J. Langley (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13421489.txt.
Description
Fragments of mitochondrial DNA floating in blood act as alarm signals that stoke inflammation, and they have been linked to outcomes in the critically ill, yet measuring them cleanly is tricky. Grant Daly and co-authors present an improved measuring workflow in this 2026 paper. Look-alike DNA stretches in the main genome can corrupt the counts.
Their workflow measures fragment amount, fragment size pattern, and variant load while sidestepping the look-alike trap. It was applied to stored samples from patients with acute respiratory failure. A cleaner assay is the precondition for judging whether these fragments deserve a place in prognosis. The authors frame the paper as a methods advance with a first clinical application, not a finished biomarker.
Catalog record
| CREATOR | Grant T. Daly, Emily M. Hartsell, Viktor M. Pastukh, Justin T. Roberts, Adeyeye I. Haastrup, Lina D. Purcell, Madhuri S. Mulekar, D. Clark Files, Peter E. Morris, Mark N. Gillespie, Raymond J. Langley |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |