Circulating tumor DNA as an arbitrator for postmastectomy radiotherapy: bridging molecular residual disease and locoregional control
Gai Liang, Qu Zhang, Mengting Yuan, Guojun Yao, Feng Yuan · 2026
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Description
Gai Liang, Qu Zhang, Mengting Yuan, Guojun Yao and Feng Yuan propose, in a 2026 commentary, using circulating tumour DNA to settle who needs radiotherapy after mastectomy. A major trial left the question open for patients whose lymph nodes cleared after chemotherapy, because overall results showed little benefit while the mastectomy subgroup hinted at real gain.
The authors connect that trial with the PREDICT-DNA study, where clearing tumour DNA from the blood after chemotherapy predicted good outcomes regardless of pathology. They suggest DNA status could act as tiebreaker: patients with lingering molecular disease would keep radiotherapy, while those cleared could safely skip it. The framework aims at de-escalation guided by molecules rather than anatomy alone.
Catalog record
| CREATOR | Gai Liang, Qu Zhang, Mengting Yuan, Guojun Yao, Feng Yuan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 8 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |