Disrupted hierarchical functional brain organization in affective and psychotic disorders: insights from functional brain gradients
Hannah Hacker, Linnea Hoheisel, Madalina-Octavia Buciuman, Annkathrin Böke, Theresa Lichtenstein, Marlene Rosen, Shalaila S. Haas, Anne Ruef, Dominic B. Dwyer, Paolo Brambilla, Carolina Bonivento, Rachel Upthegrove, Stephen J. Wood, Stefan Borgwardt, Eva Meisenzahl, Stephan Ruhrmann, Raimo K. R. Salokangas, Alessandro Bertolino, Rebekka Lencer, Udo Dannlowski, Nikolaos Koutsouleris, Lana Kambeitz-Ilankovic, Joseph Kambeitz · 2026
Read Disrupted hierarchical functional brain organization in affective and psychotic disorders: insights from functional brain gradients by Hannah Hacker, Linnea Hoheisel, Madalina-Octavia Buciuman, Annkathrin Böke, Theresa Lichtenstein, Marlene Rosen, Shalaila S. Haas, Anne Ruef, Dominic B. Dwyer, Paolo Brambilla, Carolina Bonivento, Rachel Upthegrove, Stephen J. Wood, Stefan Borgwardt, Eva Meisenzahl, Stephan Ruhrmann, Raimo K. R. Salokangas, Alessandro Bertolino, Rebekka Lencer, Udo Dannlowski, Nikolaos Koutsouleris, Lana Kambeitz-Ilankovic, Joseph Kambeitz (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13421452.txt.
Description
Hannah Hacker leads a large team looking, in a 2026 study, at how the brain's functional hierarchy is disturbed across psychosis and depression. Instead of comparing single connections, they computed brain gradients — maps that order cortex from sensory areas to higher-order regions — in 1,071 participants.
The sample covered people at clinical high risk for psychosis, recent-onset psychosis, recent-onset depression and healthy controls. Every clinical group showed changes in the visual-to-sensorimotor gradient, while only recent psychosis altered the sensory-to-association gradient. High-risk and psychosis groups scored lower in the ventral attention network, and clinical groups overall showed a compressed gradient range. Linking differences to receptor maps, the authors probe the chemistry beneath the disorder.
Catalog record
| CREATOR | Hannah Hacker, Linnea Hoheisel, Madalina-Octavia Buciuman, Annkathrin Böke, Theresa Lichtenstein, Marlene Rosen, Shalaila S. Haas, Anne Ruef, Dominic B. Dwyer, Paolo Brambilla, Carolina Bonivento, Rachel Upthegrove, Stephen J. Wood, Stefan Borgwardt, Eva Meisenzahl, Stephan Ruhrmann, Raimo K. R. Salokangas, Alessandro Bertolino, Rebekka Lencer, Udo Dannlowski, Nikolaos Koutsouleris, Lana Kambeitz-Ilankovic, Joseph Kambeitz |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |