C-glycoside synthesis through radical cross-coupling of glycohydrazides
Yinliang Guo, Yiheng Li, Benedikt Buchberger, Yixin Liu, Carla Capone, Tapas Adak, Shubham Ojha, Jasper L Tyler, Philipp Neigenfind, Molhm Nassir, Yu Kawamata, Varinder K Aggarwal, Phil S Baran · 2026
Read C-glycoside synthesis through radical cross-coupling of glycohydrazides by Yinliang Guo, Yiheng Li, Benedikt Buchberger, Yixin Liu, Carla Capone, Tapas Adak, Shubham Ojha, Jasper L Tyler, Philipp Neigenfind, Molhm Nassir, Yu Kawamata, Varinder K Aggarwal, Phil S Baran (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13421352.txt.
Description
Yinliang Guo leads a thirteen-author team describing, in a 2026 paper, a practical route to C-glycosides, sugar compounds where carbon replaces the usual oxygen link. That swap resists breakdown in the body. Several frontline diabetes drugs, the SGLT2 inhibitors, are built this way because of it. Yet making them has meant protected sugars and long sequences in the past.
Their method starts from unprotected natural sugars, converts them into hydrazide reagents, and releases sugar radicals under mild conditions for coupling to aromatic partners. The route produced all approved SGLT2 inhibitors, natural products and medicinal probes, and it forms carbon bonds at positions beyond the usual attachment point. The authors offer it as a shorter platform for sugar-based chemistry.
Catalog record
| CREATOR | Yinliang Guo, Yiheng Li, Benedikt Buchberger, Yixin Liu, Carla Capone, Tapas Adak, Shubham Ojha, Jasper L Tyler, Philipp Neigenfind, Molhm Nassir, Yu Kawamata, Varinder K Aggarwal, Phil S Baran |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31469 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |