CircZBTB46, a promising therapeutic target in crizotinib resistant ALK-positive T lymphomas
Loélia Babin, Elissa Andraos, Steffen Fuchs, Chloe Bessière, Lola Colras, Sandra Dailhau, Cathy Quelen, Cindy Pinto, Iyad Daoudi, Romain Pfeifer, Ahmed Zamani, Marina Bousquet, Stéphane Pyronnet, Christine Gaspin, Laurence Lamant, Fabienne Meggetto · 2026
Read CircZBTB46, a promising therapeutic target in crizotinib resistant ALK-positive T lymphomas by Loélia Babin, Elissa Andraos, Steffen Fuchs, Chloe Bessière, Lola Colras, Sandra Dailhau, Cathy Quelen, Cindy Pinto, Iyad Daoudi, Romain Pfeifer, Ahmed Zamani, Marina Bousquet, Stéphane Pyronnet, Christine Gaspin, Laurence Lamant, Fabienne Meggetto (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13421333.txt.
Description
Loélia Babin leads the team reporting, in a 2026 study, a circular RNA that helps an aggressive T-cell lymphoma resist treatment. The lymphoma type, ALK-positive anaplastic large-cell lymphoma, normally answers the drug crizotinib, yet resistance emerges, and the team profiled circular RNAs to find out why.
One circular RNA, circZBTB46, appeared only in the lymphoma cells, switched on by the cancer's driving fusion protein. Unlike its protein-coding parent transcript, the circular form helped drive drug resistance. Switching it off made cells and animals respond to crizotinib again. It works by soaking up a small regulatory RNA, miR-25-3p, which releases a downstream gene, PIP5K1C, to act. The authors name circZBTB46 as a treatment target.
Catalog record
| CREATOR | Loélia Babin, Elissa Andraos, Steffen Fuchs, Chloe Bessière, Lola Colras, Sandra Dailhau, Cathy Quelen, Cindy Pinto, Iyad Daoudi, Romain Pfeifer, Ahmed Zamani, Marina Bousquet, Stéphane Pyronnet, Christine Gaspin, Laurence Lamant, Fabienne Meggetto |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50923 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |