Low-normal immunoglobulin suggests monoclonal B-cell lymphocytosis and constitutional CLL susceptibility: a dual-mechanism analysis
Ramon Cohen, Shay Nemet, Shira Bezalel-Rosenberg, Ilan Asher, Keren Mahlab-Guri, Pia Raanani, Daniel Elbirt, Liron Hofstetter · 2026
Read Low-normal immunoglobulin suggests monoclonal B-cell lymphocytosis and constitutional CLL susceptibility: a dual-mechanism analysis by Ramon Cohen, Shay Nemet, Shira Bezalel-Rosenberg, Ilan Asher, Keren Mahlab-Guri, Pia Raanani, Daniel Elbirt, Liron Hofstetter (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13421330.txt.
Description
Ramon Cohen and seven colleagues report, in a 2026 cohort study, that antibody levels at the low end of normal can foreshadow chronic lymphocytic leukaemia many years later. Rather than a deficiency diagnosis, these low-normal immunoglobulin readings may betray early immune disturbance or a hidden precursor condition.
The study followed 294,712 adults aged 40 to 80 with routine antibody testing for up to ten years. Low-normal IgA carried the strongest link to later leukaemia, roughly two and a half times the risk, ahead of IgM and IgG. Checking people with low lymphocyte counts separated the signals: IgA stayed predictive while the others faded, suggesting different mechanisms. The authors read IgA's long reach — over a decade — as a constitutional susceptibility marker.
Catalog record
| CREATOR | Ramon Cohen, Shay Nemet, Shira Bezalel-Rosenberg, Ilan Asher, Keren Mahlab-Guri, Pia Raanani, Daniel Elbirt, Liron Hofstetter |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39607 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |