A novel CD7-directed antibody-drug conjugate targeting BCL-XL with potent anti-leukemic activity in T-cell acute lymphoblastic leukemia
Mariana L Oliveira, Kanokporn Nuantang, Grégoire Huré, Andrea Ávila-Ávila, Laura Bresson, Sandra Haumont, Vesela Kostova, Tibor Novak, Gaëtane Le Toumelin-Braizat, Julien Guerlesquin, Didier Demarles, Mira Merdas, Nicolas Cauquil, Oumou Goundiam, Francesca Rocchetti, Sophie Courtade-Gaiani, Damien V · 2026
Read A novel CD7-directed antibody-drug conjugate targeting BCL-XL with potent anti-leukemic activity in T-cell acute lymphoblastic leukemia by Mariana L Oliveira, Kanokporn Nuantang, Grégoire Huré, Andrea Ávila-Ávila, Laura Bresson, Sandra Haumont, Vesela Kostova, Tibor Novak, Gaëtane Le Toumelin-Braizat, Julien Guerlesquin, Didier Demarles, Mira Merdas, Nicolas Cauquil, Oumou Goundiam, Francesca Rocchetti, Sophie Courtade-Gaiani, Damien V (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13421301.txt.
Description
Oliveira and a large team built an antibody-drug conjugate aimed at T-cell acute lymphoblastic leukemia. A conjugate pairs a guiding antibody with a drug payload. This blood cancer is aggressive, and adult survival with chemotherapy stays below 50 percent. Their design steers a BCL-XL blocker straight into leukemia cells through the CD7 surface marker. The blocker disables a protein that keeps cancer cells alive.
In laboratory tests the conjugate killed most T-ALL cell lines. In mice carrying patient-derived leukemia it showed strong anti-leukemic activity, without damaging platelets. That platelet sparing matters. Free BCL-XL blockers cause severe platelet loss, the dose-limiting harm of this drug class. Combined with venetoclax, a related drug, it extended remission and mouse survival. Adding chemotherapy produced cures in some animals. The results support trials in patients.
Catalog record
| CREATOR | Mariana L Oliveira, Kanokporn Nuantang, Grégoire Huré, Andrea Ávila-Ávila, Laura Bresson, Sandra Haumont, Vesela Kostova, Tibor Novak, Gaëtane Le Toumelin-Braizat, Julien Guerlesquin, Didier Demarles, Mira Merdas, Nicolas Cauquil, Oumou Goundiam, Francesca Rocchetti, Sophie Courtade-Gaiani, Damien V |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |