Continuous renal replacement therapy for septic shock: practicalities for a pediatric intensivist
Lara Mary Titherington, Tommaso Bottesi, Francesco Guzzi, Stefano Romagnoli, Zaccaria Ricci · 2026
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Description
Titherington and colleagues present a 2026 review of high-volume blood filtration for children in septic shock, a life-threatening infection state. The treatment runs blood through a filter at high flow to clear inflammatory signals, alongside standard kidney support. The 2026 Surviving Sepsis Campaign gave it a conditional backing, despite low-certainty evidence. The review tests that stance against the data.
The targeted signals are small enough, in theory, for high-flow membranes to clear. But pediatric studies are small, single-center, and use mixed dose definitions, so their estimates are fragile. The largest observational data sets in children show no consistent benefit, and adult evidence is also weak. The idea is sound, the proof is not, and routine use should wait for stronger trials.
Catalog record
| CREATOR | Lara Mary Titherington, Tommaso Bottesi, Francesco Guzzi, Stefano Romagnoli, Zaccaria Ricci |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |