Fatty acids metabolic reprogramming and tumor microenvironment in pancreatic cancer: targeting pathways
Bassant Ehab, Ekram Saleh · 2026
Read Fatty acids metabolic reprogramming and tumor microenvironment in pancreatic cancer: targeting pathways by Bassant Ehab, Ekram Saleh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13421207.txt.
Description
Bassant Ehab and Ekram Saleh review, in a 2026 paper, how pancreatic ductal adenocarcinoma rewires its use of fatty acids to survive in a harsh, oxygen-poor tumour environment. Fatty acids serve the cancer as fuel, building material and signalling molecules, so their handling is closely tied to growth and treatment resistance.
The authors catalogue the enzymes and regulators that control fatty acid synthesis, uptake, storage and burning, and they explain how genetic changes push the tumour toward making or scavenging lipids. They also describe how surrounding tissue supplies extra lipid and supports the cancer's metabolism. The review ends with drugs that interfere with these pathways, presented as a route to weakening the tumour and improving response to existing therapy.
Catalog record
| CREATOR | Bassant Ehab, Ekram Saleh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |