Real‑world analysis of Macular Oedema associated with Paclitaxel Formulations using the Japanese Adverse Drug Event Report database
Koki Takeda, Toshinori Hirai, Ayu Sugioka, Rinka Okamura, Asako Nishimura, Nobuhito Shibata, Junzheng Yang, Junzheng Yang, Junzheng Yang · 2026
Read Real‑world analysis of Macular Oedema associated with Paclitaxel Formulations using the Japanese Adverse Drug Event Report database by Koki Takeda, Toshinori Hirai, Ayu Sugioka, Rinka Okamura, Asako Nishimura, Nobuhito Shibata, Junzheng Yang, Junzheng Yang, Junzheng Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13419171.txt.
Description
Koki Takeda and colleagues mine a national drug safety database in Japan for reports of macular swelling tied to a common cancer drug. The drug, paclitaxel, comes in a standard form and in a protein-bound form used for several cancers. Their set held 585,738 adverse event reports in total, of which 123 involved swelling at the center of the retina.
Adjusted reporting odds reached 9.4 for the standard form and 47.0 for the protein-bound form in the main comparison, both far above the no-signal line. Diabetes and use of certain glaucoma eye drops also carried raised signals in the same data. Such database studies cannot prove cause, yet the strength of the gap marks eye checks as worth weighing for patients on this drug.
Catalog record
| CREATOR | Koki Takeda, Toshinori Hirai, Ayu Sugioka, Rinka Okamura, Asako Nishimura, Nobuhito Shibata, Junzheng Yang, Junzheng Yang, Junzheng Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |