CCNA2, MAD2L1, AURKA, and PTTG1 promote proliferation and migration in hepatocellular carcinoma
Wang Jinli, Hu Shiping · 2026
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Description
Wang Jinli and colleagues hunted hub genes in liver cancer in 2026 by merging four public gene-expression datasets. Hepatocellular carcinoma kills largely because late disease has few good treatments, so the team sought central drivers among 147 genes shared across all four datasets.
Four hubs emerged, CCNA2, MAD2L1, AURKA, and PTTG1, all tied to cell division and chromosome stability, all overactive in tumors, and all linked to later stage and poorer survival. Silencing them slowed cancer cell growth and movement in lab tests, nominating the quartet as diagnostic and drug targets.
Catalog record
| CREATOR | Wang Jinli, Hu Shiping |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |