Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han · 2026
Read Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV by Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13418511.txt.
Description
Kong and colleagues profiled immune cells in 2026 from pigs vaccinated against a major swine virus. Porcine reproductive and respiratory syndrome virus costs the pig industry heavily, and why some vaccines protect fully is unclear. The team combined single-cell gene readings with T cell receptor profiling in animals that ended up fully, partly, or not protected after virus challenge.
Protected animals held distinct CD8 subsets marked by clonal expansion, meaning many copies of the same cell, and strong killing programmes. Unprotected animals instead piled up worn-out CD8 cells bearing exhaustion markers such as CTLA4. Swapping the virus's structural protein region reshaped the cell mix toward the protective pattern and improved outcomes. Full activation also needed signals from macrophages and help from CD4 cells.
Catalog record
| CREATOR | Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |