Stress-specific 14-3-3–client modules in digestive cancers: an evidence-graded review of adaptive survival and therapy resistance
Rudong Li, Zhipeng Zhao, Xudong Wang · 2026
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Description
Rudong Li, Zhipeng Zhao, and Xudong Wang review adaptor proteins called 14-3-3 and their partner proteins in digestive cancers, in a 2026 evidence graded review. These adaptors grab tagged partners and change their place, stability, and activity under stress. The review grades partner modules in stomach, bowel, pancreatic, liver, and bile duct cancers by strength of proof.
Named pairings explain drug tolerance in each cancer: one shields a death protein in stomach cancer, others sustain stress responses or gemcitabine resistance elsewhere. Liver and bile modules look context dependent so far. The useful unit is the specific stressed pairing, not total adaptor levels, the authors argue.
Catalog record
| CREATOR | Rudong Li, Zhipeng Zhao, Xudong Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |