Observation of inflammation and macrophage polarization in an experimental model of cigarette smoke-exposed mice and cigarette smoke extract (CSE)-induced RAW264.7 cells: An experimental preclinical study
Jiazhen Zhao, Yang Liu, Yaxi Li, Zhiyuan Liu, Min Tan, Changhui Wang, Xuan Long, Xiaolian Song · 2026
Read Observation of inflammation and macrophage polarization in an experimental model of cigarette smoke-exposed mice and cigarette smoke extract (CSE)-induced RAW264.7 cells: An experimental preclinical study by Jiazhen Zhao, Yang Liu, Yaxi Li, Zhiyuan Liu, Min Tan, Changhui Wang, Xuan Long, Xiaolian Song (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13417965.txt.
Description
Jiazhen Zhao and colleagues model smoke driven lung inflammation in mice and in cultured immune cells, in a 2026 preclinical study at a Shanghai hospital. The work targets chronic obstructive pulmonary disease, where macrophages, the lung's cleaner cells, skew toward an attack mode. Mice breathed cigarette smoke for 15 weeks with two bacterial signal doses, while cells received smoke extract for a day.
Exposed mice showed poorer airflow, higher lung resistance, and damaged air sacs. Attack mode markers and inflammatory signals rose, while a calming signal fell, in both mice and cells. A pathway pairing NF-kB with the NLRP3 inflammasome stayed active, suggesting a target for calming smoke driven inflammation.
Catalog record
| CREATOR | Jiazhen Zhao, Yang Liu, Yaxi Li, Zhiyuan Liu, Min Tan, Changhui Wang, Xuan Long, Xiaolian Song |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |