Solvent-controlled Rh-catalysed hydrodehalogenation and construction of phenanthridinone skeleton from a common precursor in one-step sequence and the antitumor activity of its derivatives
De-Xuan Hu, Chao Qin, Xiang Gao, Ling Tang, Yaxin Zheng, Rui Yin · 2026
Read Solvent-controlled Rh-catalysed hydrodehalogenation and construction of phenanthridinone skeleton from a common precursor in one-step sequence and the antitumor activity of its derivatives by De-Xuan Hu, Chao Qin, Xiang Gao, Ling Tang, Yaxin Zheng, Rui Yin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13417644.txt.
Description
De-Xuan Hu and colleagues show that solvent choice steers one rhodium catalysed reaction toward two different products, in a 2026 study. Starting from the same halogen bearing benzamide, an alcohol solvent strips the halogen cleanly, while a non water like solvent builds a phenanthridinone ring system instead. Both routes run efficiently in one step.
Related ring compounds were then tested against two DNA repair enzymes and for cancer cell killing. One compound blocked the first enzyme strongly and boosted a known drug's effect in colon cancer cells. Another blocked the second enzyme and shrank tumours in mice. The chemistry doubles as a drug lead source.
Catalog record
| CREATOR | De-Xuan Hu, Chao Qin, Xiang Gao, Ling Tang, Yaxin Zheng, Rui Yin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |