Immunogenicity of an Oil-in-Water Emulsion Containing Hafnia Alvei-Derived Lipopolysaccharide, with TLR4 and Dectin-2 Agonist Activity In Vitro
Ri Ra Hong, Eun Ji Lee, Ji Hee Kwon, Sun Woo Im, Yeji Nam, Hyun-Tae Son, Eunhye Yoo, Hyung Tae Lee · 2026
Read Immunogenicity of an Oil-in-Water Emulsion Containing Hafnia Alvei-Derived Lipopolysaccharide, with TLR4 and Dectin-2 Agonist Activity In Vitro by Ri Ra Hong, Eun Ji Lee, Ji Hee Kwon, Sun Woo Im, Yeji Nam, Hyun-Tae Son, Eunhye Yoo, Hyung Tae Lee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13417346.txt.
Description
Ri Ra Hong and colleagues test a bacterial surface molecule from a gut friendly microbe as a possible vaccine booster, in a 2026 immunology study. The molecule, lipopolysaccharide from Hafnia alvei, triggers innate immunity. Pathogenic versions can overstimulate, so a commensal source may offer a gentler profile. Cell and reporter tests spanned several host species.
The molecule matched Escherichia coli material in strength and beat two pathogen sources on one key signal. Uniquely, it activated two receptors, TLR4 and Dectin-2. Mixed into an oil in water emulsion with a model antigen, it raised antibody and cell responses in animals with no early safety flags. More work must confirm value.
Catalog record
| CREATOR | Ri Ra Hong, Eun Ji Lee, Ji Hee Kwon, Sun Woo Im, Yeji Nam, Hyun-Tae Son, Eunhye Yoo, Hyung Tae Lee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32459 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |