Clinical Activity of RET TKI Plus Chemotherapy After Progression on a RET TKI in a RET Fusion–Positive NSCLC Real-World Cohort: A Brief Report
Alvaro Guimaraes Paula, Ximeng Liu, Amirali Karimi, Kyle Concannon, Simon Heeke, Yasir Y. Elamin, Kaiwen Wang, Jenny V. Pozadzides, Natalie Vokes, Janet Tu, Anne Tsao, Marcelo V. Negrao, Jianjun Zhang, Eric K. Singhi, Bingman Zhang, Waree Rinsurongkawong, Isadora Guimaraes Martins, Hai T. Tran, Don L. Gibbons, Monique B. Nilsson, John V. Heymach · 2026
Read Clinical Activity of RET TKI Plus Chemotherapy After Progression on a RET TKI in a RET Fusion–Positive NSCLC Real-World Cohort: A Brief Report by Alvaro Guimaraes Paula, Ximeng Liu, Amirali Karimi, Kyle Concannon, Simon Heeke, Yasir Y. Elamin, Kaiwen Wang, Jenny V. Pozadzides, Natalie Vokes, Janet Tu, Anne Tsao, Marcelo V. Negrao, Jianjun Zhang, Eric K. Singhi, Bingman Zhang, Waree Rinsurongkawong, Isadora Guimaraes Martins, Hai T. Tran, Don L. Gibbons, Monique B. Nilsson, John V. Heymach (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13416825.txt.
Description
Alvaro Guimaraes Paula and a large team report outcomes for lung cancer patients whose tumours carry a RET fusion, in a 2026 brief report. Targeted RET drugs are the usual first treatment, yet cancers often learn to resist them. The team compares chemotherapy paired with a RET drug against chemotherapy paired with immunotherapy after resistance appears.
Only 12 patients were included in this real world group. Time without growth was longer with the RET pairing, at a median near 7.8 months versus 3.5 months. Response rates were also a little higher. Blood related side effects at severe grade were more common with the RET pairing, so benefits came with added risk.
Catalog record
| CREATOR | Alvaro Guimaraes Paula, Ximeng Liu, Amirali Karimi, Kyle Concannon, Simon Heeke, Yasir Y. Elamin, Kaiwen Wang, Jenny V. Pozadzides, Natalie Vokes, Janet Tu, Anne Tsao, Marcelo V. Negrao, Jianjun Zhang, Eric K. Singhi, Bingman Zhang, Waree Rinsurongkawong, Isadora Guimaraes Martins, Hai T. Tran, Don L. Gibbons, Monique B. Nilsson, John V. Heymach |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28238 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |