Dynamic Co‐Evolution of Obesity‐Metabolic‐Inflammatory for Cardiovascular Disease Risk Stratification in Middle‐Aged and Older Adults: A Data‐Driven Joint Trajectory Analysis
Qinggao Wang, Yilu Lei, Qingfeng Zhou, Yan Long, Yinjuan Lai · 2026
Read Dynamic Co‐Evolution of Obesity‐Metabolic‐Inflammatory for Cardiovascular Disease Risk Stratification in Middle‐Aged and Older Adults: A Data‐Driven Joint Trajectory Analysis by Qinggao Wang, Yilu Lei, Qingfeng Zhou, Yan Long, Yinjuan Lai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13416755.txt.
Description
Wang and colleagues argue that heart risk in later life is better read from how weight, blood sugar control, and inflammation travel together than from any single checkup. Their 2026 study uses a Chinese aging cohort of 4,483 adults aged forty five and over. It tracks body mass index, a glucose fat index, and an inflammation marker across 2011 to 2015, clusters the paths, then follows heart disease and stroke to 2020.
Four paths emerged: a steady low risk group near half the cohort, an obesity led group, a metabolic and obesity group, and an inflammation led group. Over five years, 592 people developed cardiovascular disease. Every adverse path carried higher risk than the low path after adjustment, with hazard ratios above one third higher. The link ran strongest for stroke in the metabolic and obesity group. Trajectory screening could flag high risk adults snapshot scores miss.
Catalog record
| CREATOR | Qinggao Wang, Yilu Lei, Qingfeng Zhou, Yan Long, Yinjuan Lai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |