Cerebrospinal Fluid Concentrations of Bedaquiline, Pretomanid, and Linezolid During Curative Treatment of Fluoroquinolone-Resistant Pre–Extensively Drug-Resistant Tuberculous Meningitis
Adrian Robert Tramontana, Andrew Burke, Maria Globan, Brett McWhinney, Aaron E Bloch, Benjamin J Smith, Justin T Denholm, Connor James Wright, James S Molton · 2026
Read Cerebrospinal Fluid Concentrations of Bedaquiline, Pretomanid, and Linezolid During Curative Treatment of Fluoroquinolone-Resistant Pre–Extensively Drug-Resistant Tuberculous Meningitis by Adrian Robert Tramontana, Andrew Burke, Maria Globan, Brett McWhinney, Aaron E Bloch, Benjamin J Smith, Justin T Denholm, Connor James Wright, James S Molton (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13416743.txt.
Description
Tramontana and colleagues report a 2026 case study of drug levels in spinal fluid during treatment of drug-resistant tuberculosis meningitis, an infection of the membranes around the brain. A drug mix called BPaL has transformed care for resistant lung tuberculosis, but proof for the brain form is thin. One patient was cured on a ten-month course of BPaL plus two added drugs.
The team measured the three BPaL drugs in blood and spinal fluid across a full day. Pretomanid entered freely, matched its free blood level, and stayed above the bacteria-killing level most of the day. Linezolid also entered well, close to its free blood level. These readings give rare hard numbers for dosing, where too little drug can mean death or lasting harm. One case cannot set doses for all, but it supports formal trials.
Catalog record
| CREATOR | Adrian Robert Tramontana, Andrew Burke, Maria Globan, Brett McWhinney, Aaron E Bloch, Benjamin J Smith, Justin T Denholm, Connor James Wright, James S Molton |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |