Estimated Tubular Secretion of Creatinine and Risk of Kidney Failure: The AASK Trial
Pranav S Garimella, Kevin M Cummins, Jennifer Gassman, Francis Gabbai, Andrew S Levey, Joachim H Ix · 2026
Read Estimated Tubular Secretion of Creatinine and Risk of Kidney Failure: The AASK Trial by Pranav S Garimella, Kevin M Cummins, Jennifer Gassman, Francis Gabbai, Andrew S Levey, Joachim H Ix (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13416659.txt.
Description
Pranav S Garimella and colleagues report a letter on kidney function in the AASK trial, published in 2026. They ask whether a simple estimate of how much creatinine the kidney tubules secrete can stand in for a direct measure. The estimate comes from the gap between creatinine clearance and estimated filtration rate.
The analysis covers 999 trial participants who had measured filtration, estimated filtration, and urine creatinine clearance at baseline. Lower secretion had earlier been linked to kidney failure needing replacement therapy. Readers learn why the easier estimate could let large studies assess tubular health without hard isotope tests, and which outcomes the team tracked, including heart disease and death.
Catalog record
| CREATOR | Pranav S Garimella, Kevin M Cummins, Jennifer Gassman, Francis Gabbai, Andrew S Levey, Joachim H Ix |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 12595 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |