Response to the Letter by Tsuboi and Sasaki: “Integrating Podocyte Biology into the Two-Stage Remission Model”
Rutger J Maas, Bartholomeus T van den Berge · 2026
Read Response to the Letter by Tsuboi and Sasaki: “Integrating Podocyte Biology into the Two-Stage Remission Model” by Rutger J Maas, Bartholomeus T van den Berge (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13416654.txt.
Description
Rutger Maas and Bartholomeus van den Berge replied in 2026 to a letter about remission in a kidney filter disease. In minimal change disease, the filters leak protein into urine, and steroid drugs are the main treatment. Tsuboi and Sasaki had proposed a two-stage model: partial remission shows the immune attack easing, while full remission waits on the kidney's reserve of filters.
The reply argues that filter reserve shapes the response from the very start. Protein in urine falls in two phases, fast then slow, and the fast phase already trends slower in patients with fewer filters. Urine tests of shed filter cells also vary at partial remission. The authors propose that stage two hinges on repair of the filter's fine slits.
Catalog record
| CREATOR | Rutger J Maas, Bartholomeus T van den Berge |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |