IKZF1基因改变在急性B淋巴细胞白血病中的预后意义及移植策略选择

Description

Ma Xiaoxiao and Jiang Erlie wrote a review dated two thousand twenty-six, in Chinese, on a gene change that worsens outlook in a childhood leukemia. The cancer is B-cell acute lymphoblastic leukemia. Faults in the gene IKZF1 are common in it and track with higher relapse risk and poor prognosis.

The review explains what the gene does and what its many change types mean in the clinic. It then builds a decision framework that runs from diagnosis through transplant planning and beyond. Immune therapy serves as a bridge to transplant, and the choice of transplant type is guided by how fast measurable disease clears. Follow-up care keys on the same measure.

Catalog record

Source: https://europepmc.org/articles/PMC13416543