Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium
Kyong T. Fam, Pavan Kumar Chodisetti, Zifei Wang, Joshua A. Homer, Christopher J. Smedley, Seiya Kitamura, Benjamin Silva, Yijun Xiong, Althea Hansel-Harris, Matthew Holcomb, Simeon Babarinde, Adrianna M. Turner, Daria Van Tyne, Ian A. Wilson, Stefano Forli, Benjamin F. Cravatt, Donghyun Park, Dennis W. Wolan, John E. Moses, Howard C. Hang · 2026
Read Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium by Kyong T. Fam, Pavan Kumar Chodisetti, Zifei Wang, Joshua A. Homer, Christopher J. Smedley, Seiya Kitamura, Benjamin Silva, Yijun Xiong, Althea Hansel-Harris, Matthew Holcomb, Simeon Babarinde, Adrianna M. Turner, Daria Van Tyne, Ian A. Wilson, Stefano Forli, Benjamin F. Cravatt, Donghyun Park, Dennis W. Wolan, John E. Moses, Howard C. Hang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13416122.txt.
Description
Kyong T. Fam leads a large team showing that blocking a bacterial wall remodeling enzyme restores vancomycin's power against resistant Enterococcus faecium, in 2026. The enzyme, SagA, snips peptidoglycan, the mesh forming the bacterial wall. Cutting its gene stunted wall repair and growth in the drug proof germ.
New bond forming blockers, the first for this enzyme family, gave the same softening effect in dishes. Vancomycin worked better across distinct patient strains once SagA was shut down, and the effect held in live infection models too. Wall hydrolases join the list of druggable helpers that could rescue old antibiotics.
Catalog record
| CREATOR | Kyong T. Fam, Pavan Kumar Chodisetti, Zifei Wang, Joshua A. Homer, Christopher J. Smedley, Seiya Kitamura, Benjamin Silva, Yijun Xiong, Althea Hansel-Harris, Matthew Holcomb, Simeon Babarinde, Adrianna M. Turner, Daria Van Tyne, Ian A. Wilson, Stefano Forli, Benjamin F. Cravatt, Donghyun Park, Dennis W. Wolan, John E. Moses, Howard C. Hang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 116481 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |