Development and Validation of a Liquid Chromatography/Tandem Mass Spectrometry Method for the Quantification of the GLP-1 Analog Semaglutide in Rat Plasma, and Its Application in a Pharmacokinetic Study
Jong-Min Kim, Kyoung-Ah Kim, Na-Young Yu, Dae-Duk Kim, Jeong Yeon Kang, Seung-Ki Baek, Jin-Woo Park, Ji-Young Park · 2026
Read Development and Validation of a Liquid Chromatography/Tandem Mass Spectrometry Method for the Quantification of the GLP-1 Analog Semaglutide in Rat Plasma, and Its Application in a Pharmacokinetic Study by Jong-Min Kim, Kyoung-Ah Kim, Na-Young Yu, Dae-Duk Kim, Jeong Yeon Kang, Seung-Ki Baek, Jin-Woo Park, Ji-Young Park (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13415238.txt.
Description
Jong-Min Kim and colleagues validate a faster blood test for the diabetes and obesity drug semaglutide in 2026. Measuring this GLP-1 mimic in plasma supports drug level studies, yet older methods took about eighteen minutes per run. Their liquid chromatography and mass spectrometry assay finishes within nine minutes.
Only fifty microliters of rat plasma are needed, cleaned by precipitation and solid phase extraction. The assay measured reliably from 1 to 500 nanograms per milliliter, with accuracy near 95 to 104 percent. Stability held under every tested condition. A rat dosing study at fifty micrograms showed the method works in practice.
Catalog record
| CREATOR | Jong-Min Kim, Kyoung-Ah Kim, Na-Young Yu, Dae-Duk Kim, Jeong Yeon Kang, Seung-Ki Baek, Jin-Woo Park, Ji-Young Park |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28562 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |