Human vaccine responses regulated by parallel cytokine pathways
Guangbo Chen, Jing Guo, John Heath, Tyler R Prestwood, Woo Joo Kwon, Ashley R Smith, Tran T Nguyen, Karan R Kathuria, Elsa Sola, AbuBakr Sangare, Vamsee Mallajosyula, Ryan Furuichi Fong, Azam Mohsin, Lei Chen, Oviya Siva, Cindy Padilla, Mingdian Tan, Cornelia L Dekker, Philip Grant, Ying Lu, Harry B Greenberg, William H Robinson, Catherine Blish, Shai S Shen-Orr, Ahmad Salehi, Holden T Maecker, Purvesh Khatri, Paul J Utz, Yueh-Hsiu Chien, Mark M Davis · 2026
Read Human vaccine responses regulated by parallel cytokine pathways by Guangbo Chen, Jing Guo, John Heath, Tyler R Prestwood, Woo Joo Kwon, Ashley R Smith, Tran T Nguyen, Karan R Kathuria, Elsa Sola, AbuBakr Sangare, Vamsee Mallajosyula, Ryan Furuichi Fong, Azam Mohsin, Lei Chen, Oviya Siva, Cindy Padilla, Mingdian Tan, Cornelia L Dekker, Philip Grant, Ying Lu, Harry B Greenberg, William H Robinson, Catherine Blish, Shai S Shen-Orr, Ahmad Salehi, Holden T Maecker, Purvesh Khatri, Paul J Utz, Yueh-Hsiu Chien, Mark M Davis (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13414556.txt.
Description
Guangbo Chen and co-authors hunt in 2026 for blood signals that mark who answers a flu shot well. Antibody response to the killed flu vaccine swings widely from person to person, for reasons still unclear. The team read 66 cytokines in four vaccine groups across five seasons, 581 people in all. Two blood signals stood out: IL-18 and IFN-beta. High starting levels of each went with stronger antibody counts at day 28.
Cause tests moved to lab-grown tonsil and spleen tissue. There, type I interferons, IL-21, and IL-12 raised antibody output. IL-18 did not, despite its mark in blood. IL-12 was found to switch on IL-21 in human cells, a path that runs beside the interferon path. Sent by mRNA flecks in live tests, IL-21 or IFN-beta built long-lived antibody cells.
Catalog record
| CREATOR | Guangbo Chen, Jing Guo, John Heath, Tyler R Prestwood, Woo Joo Kwon, Ashley R Smith, Tran T Nguyen, Karan R Kathuria, Elsa Sola, AbuBakr Sangare, Vamsee Mallajosyula, Ryan Furuichi Fong, Azam Mohsin, Lei Chen, Oviya Siva, Cindy Padilla, Mingdian Tan, Cornelia L Dekker, Philip Grant, Ying Lu, Harry B Greenberg, William H Robinson, Catherine Blish, Shai S Shen-Orr, Ahmad Salehi, Holden T Maecker, Purvesh Khatri, Paul J Utz, Yueh-Hsiu Chien, Mark M Davis |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69314 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |