Exploring the Predictive Value of Circulating Cell-Free DNA Within a Multiparameter Panel for Hepatocellular Carcinoma Detection
Ioana Manea, Speranta Maria Iacob, Razvan Iacob, Alina-Veronica Ghionescu, Andrei Sorop, Roxana Elena Saizu, Daria-Ana-Arina Gheorghe, Delia Prisecariu, Simona Olimpia Dima, Liliana Simona Gheorghe · 2026
Read Exploring the Predictive Value of Circulating Cell-Free DNA Within a Multiparameter Panel for Hepatocellular Carcinoma Detection by Ioana Manea, Speranta Maria Iacob, Razvan Iacob, Alina-Veronica Ghionescu, Andrei Sorop, Roxana Elena Saizu, Daria-Ana-Arina Gheorghe, Delia Prisecariu, Simona Olimpia Dima, Liliana Simona Gheorghe (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13413274.txt.
Description
Ioana Manea and colleagues ask in 2026 whether the length of DNA fragments floating in blood can sharpen liver cancer detection. The standard marker, alpha-fetoprotein, misses many early tumours in people with chronic liver disease. In a prospective cohort of 125 such patients, the team measured fragment size by chip electrophoresis and tested it alone and inside multi-marker panels against the reference marker.
Fragments ran significantly shorter in patients whose cirrhosis had turned cancerous than in cirrhosis alone. Added to a panel of alpha-fetoprotein, age, and liver reserve, though, fragment size brought no significant gain in their analysis. Age and platelet count proved the strongest independent predictors in this exploratory cohort. The authors want larger validation before judging the marker's true worth.
Catalog record
| CREATOR | Ioana Manea, Speranta Maria Iacob, Razvan Iacob, Alina-Veronica Ghionescu, Andrei Sorop, Roxana Elena Saizu, Daria-Ana-Arina Gheorghe, Delia Prisecariu, Simona Olimpia Dima, Liliana Simona Gheorghe |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34563 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |