Ras1-Independent High Iron-Mediated Hyphal Formation in Candida albicans
Deepak Parashar, Rishabh Sharma, Sumant Puri · 2026
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Description
Deepak Parashar, Rishabh Sharma, and Sumant Puri show in 2026 that plentiful iron lets the yeast Candida albicans grow its invasive thread form without a master switch long thought essential. The switch, a small protein called Ras1, normally reads a sugar signal and starts hyphal growth through a well-known pathway. Working in cell cultures and in a worm gut colonization model, the team varied iron while feeding the yeast that sugar signal.
Cells lacking Ras1 formed true hyphae only when iron ran high; the parent strain filamented regardless of iron levels. The iron route skipped the usual signal molecule yet still needed two downstream factors, Efg1 and Tpk2. Gene readings showed iron repressed a brake protein, and restoring that brake blocked the effect entirely.
Catalog record
| CREATOR | Deepak Parashar, Rishabh Sharma, Sumant Puri |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30171 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |