Increased high sensitivity C-reactive protein in more severe wheeze/asthma phenotypes in child- and adulthood in ALLIANCE
Lena Lagally, Lena Ullemeyer, Jimmy Omony, Kristina Gottschau, Francesco Foppiano, Mustafa Abdo, Vera Veith, Clemens Thölken, Alexander Hose, Nicole Maison, Ruth Grychtol, Anna-Maria Dittrich, Lennart Riemann, Markus Weckmann, Inke König, Lea Kronziel, Sabina Illi, Silke van Koningsbruggen-Rietschel, Klaus F Rabe, Harald Renz, Gesine Hansen, Folke Brinkmann, Matthias V Kopp, Erika von Mutius, Thomas Bahmer, Markus Ege, Chrysanthi Skevaki, Bianca Schaub, ALLIANCE Study Group · 2026
Read Increased high sensitivity C-reactive protein in more severe wheeze/asthma phenotypes in child- and adulthood in ALLIANCE by Lena Lagally, Lena Ullemeyer, Jimmy Omony, Kristina Gottschau, Francesco Foppiano, Mustafa Abdo, Vera Veith, Clemens Thölken, Alexander Hose, Nicole Maison, Ruth Grychtol, Anna-Maria Dittrich, Lennart Riemann, Markus Weckmann, Inke König, Lea Kronziel, Sabina Illi, Silke van Koningsbruggen-Rietschel, Klaus F Rabe, Harald Renz, Gesine Hansen, Folke Brinkmann, Matthias V Kopp, Erika von Mutius, Thomas Bahmer, Markus Ege, Chrysanthi Skevaki, Bianca Schaub, ALLIANCE Study Group (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13412301.txt.
Description
Lena Lagally and co-authors examine in 2026 whether a sensitive inflammation marker rises with asthma severity across childhood and adult life. High-sensitivity C-reactive protein, or hsCRP, detects the low-grade inflammation standard tests miss. Within the ALLIANCE all-age asthma cohort, the team measured hsCRP in 944 participants, 728 of them children, and related levels to a validated severity score and its parts.
Adults with asthma carried higher hsCRP than healthy controls, and levels climbed with clinical severity at every age. The severity score correlated with hsCRP in patients aged six and older. Inhaled steroid use linked to lower hsCRP in preschool wheezers yet higher levels in adults, a split the authors read as reflecting disease course rather than drug effect alone.
Catalog record
| CREATOR | Lena Lagally, Lena Ullemeyer, Jimmy Omony, Kristina Gottschau, Francesco Foppiano, Mustafa Abdo, Vera Veith, Clemens Thölken, Alexander Hose, Nicole Maison, Ruth Grychtol, Anna-Maria Dittrich, Lennart Riemann, Markus Weckmann, Inke König, Lea Kronziel, Sabina Illi, Silke van Koningsbruggen-Rietschel, Klaus F Rabe, Harald Renz, Gesine Hansen, Folke Brinkmann, Matthias V Kopp, Erika von Mutius, Thomas Bahmer, Markus Ege, Chrysanthi Skevaki, Bianca Schaub, ALLIANCE Study Group |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |