CircSPARC promotes esophageal squamous cell carcinoma through an HNRNPC–EPN2 splicing axis that activates Wnt/β-Catenin signaling
Suli Dai, Cong Zhang, Zishuan Wei, Yaxin Liu, Yang Wen, Jinxia Chen, Xiaoya Li, Sisi Wei, Guogui Sun, Lianmei Zhao · 2026
Read CircSPARC promotes esophageal squamous cell carcinoma through an HNRNPC–EPN2 splicing axis that activates Wnt/β-Catenin signaling by Suli Dai, Cong Zhang, Zishuan Wei, Yaxin Liu, Yang Wen, Jinxia Chen, Xiaoya Li, Sisi Wei, Guogui Sun, Lianmei Zhao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13411977.txt.
Description
Suli Dai and colleagues traced in 2026 how a circular RNA, circSPARC, drives esophageal squamous cell cancer through a growth signal. The Wnt pathway stays switched on in this cancer, yet how circular RNAs keep it running was unclear, so the team combined lab and animal tests with RNA binding studies.
CircSPARC grips a processing protein, HNRNPC, to block a protective long form of EPN2. That form normally helps clear a Wnt receptor from the cell surface, leaving the growth signal stuck on. Restoring that long form slowed the cancer, pointing drug hunters toward breaking the circSPARC grip as a new treatment angle.
Catalog record
| CREATOR | Suli Dai, Cong Zhang, Zishuan Wei, Yaxin Liu, Yang Wen, Jinxia Chen, Xiaoya Li, Sisi Wei, Guogui Sun, Lianmei Zhao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |