Structural basis for substrate recognition and inhibition of human glucose-6-phosphate transporter SLC37A4
Hui Li, Xiaomin Peng, Yuwen Huang, Wencheng Wu, Nan Li, Ziqi Cheng, Xuepeng Wei, Richard Hodge, Richard Hodge, Richard Hodge, Richard Hodge · 2026
Read Structural basis for substrate recognition and inhibition of human glucose-6-phosphate transporter SLC37A4 by Hui Li, Xiaomin Peng, Yuwen Huang, Wencheng Wu, Nan Li, Ziqi Cheng, Xuepeng Wei, Richard Hodge, Richard Hodge, Richard Hodge, Richard Hodge (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13411879.txt.
Description
Hui Li and colleagues capture in 2026 the three-dimensional shape of the human transporter that moves glucose-6-phosphate into the cell's processing compartment. That handoff keeps blood sugar steady, and faults in the transporter cause a glycogen storage disease. How it recognizes cargo and swaps it for phosphate was unknown.
Frozen microscopy delivered structures in three states: empty, cargo-loaded, and locked by a plant compound. The transporter cradles its negatively charged cargo in a positive pocket, rocking between outward- and inward-facing shapes to trade molecules across the membrane. The plant compound jams the inward state from the cell side, freezing the cycle. Disease variant tests backed the rocking-switch picture the structures suggest.
Catalog record
| CREATOR | Hui Li, Xiaomin Peng, Yuwen Huang, Wencheng Wu, Nan Li, Ziqi Cheng, Xuepeng Wei, Richard Hodge, Richard Hodge, Richard Hodge, Richard Hodge |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |