Spatiotemporal regulation of DNA repair proteins between Golgi and nucleus maintains genome stability
George Galea, Karolina Kuodyte, Muzamil Majid Khan, Peter J Thul, Beate Neumann, Emma Lundberg, Rainer Pepperkok · 2026
Read Spatiotemporal regulation of DNA repair proteins between Golgi and nucleus maintains genome stability by George Galea, Karolina Kuodyte, Muzamil Majid Khan, Peter J Thul, Beate Neumann, Emma Lundberg, Rainer Pepperkok (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13411647.txt.
Description
George Galea and co-workers uncover in 2026 a holding bay for DNA repair: the Golgi apparatus, the cell's shipping hub, parks a repair protein until damage calls it into the nucleus. How the Golgi and nucleus coordinate was poorly understood. Systematic screening of proteins living in both places exposed a whole repair network.
The repair protein RAD51C sits anchored to a Golgi giant called giantin during quiet times. DNA damage flips a signal through the ATM kinase, cutting RAD51C loose for nuclear import. Timing and place thus gate genome protection, with the Golgi acting as a regulated reservoir. Disrupting the anchor or the release signal would predictably leave cells exposed, a vulnerability the study maps for future work.
Catalog record
| CREATOR | George Galea, Karolina Kuodyte, Muzamil Majid Khan, Peter J Thul, Beate Neumann, Emma Lundberg, Rainer Pepperkok |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |