Exploratory Immunophenotyping of Programmed cell death-1 (PD-1) Expression and Regulatory T-Cell (Treg) Profiles in Systemic Lupus Erythematosus and Healthy Controls: A Cohort Study with Illustrative Clinical Cases
Po-Jen Hsiao, Jeng-Wei Lu, Yi-Jung Ho, Shan-Wen Lui, Ting-Yu Hsieh, Wun-Long Jheng, Anna Blyzniuk, Feng-Cheng Liu · 2026
Read Exploratory Immunophenotyping of Programmed cell death-1 (PD-1) Expression and Regulatory T-Cell (Treg) Profiles in Systemic Lupus Erythematosus and Healthy Controls: A Cohort Study with Illustrative Clinical Cases by Po-Jen Hsiao, Jeng-Wei Lu, Yi-Jung Ho, Shan-Wen Lui, Ting-Yu Hsieh, Wun-Long Jheng, Anna Blyzniuk, Feng-Cheng Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13411475.txt.
Description
Po-Jen Hsiao and co-authors profile in 2026 immune brake signals and regulatory T cells in lupus patients versus healthy volunteers. Both the brake protein PD-1 and the calming Treg cells keep immunity balanced, and both misbehave in lupus. How their profiles shift between flare and calm was the open question.
Flow cytometry measured many cell features at once in twenty healthy Taiwanese controls and ten lupus patients. Lupus samples varied far more between individuals in brake signal levels and Treg makeup. Paired samples from active and stable phases, plus a few infection and post-surgery cases, added context. Small numbers make every result exploratory, the authors stress, fit for generating hypotheses rather than guiding treatment.
Catalog record
| CREATOR | Po-Jen Hsiao, Jeng-Wei Lu, Yi-Jung Ho, Shan-Wen Lui, Ting-Yu Hsieh, Wun-Long Jheng, Anna Blyzniuk, Feng-Cheng Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33871 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |