Ferritin Iron Mineralisation: Route of Fe3+ Transfer From the Ferroxidase Centre to the Inner Cavity of Human H‐Chain Ferritin
Zinnia Bugg, Justin M Bradley, Andrew M Hemmings, Nick E Le Brun · 2026
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Description
Zinnia Bugg and colleagues traced in 2026 how iron moves inside human ferritin, the protein that stores iron safely. Ferritin first oxidizes iron at a two-iron site called the ferroxidase centre, yet the route the oxidized iron then takes to the hollow core where the mineral grows was unknown.
Time-resolved crystal snapshots caught three extra iron spots, all tied to one amino acid, Glu61, and swapping that residue blocked the route without slowing the first oxidation step. The paper maps a key handoff in iron storage, which matters for disorders where iron handling goes wrong.
Catalog record
| CREATOR | Zinnia Bugg, Justin M Bradley, Andrew M Hemmings, Nick E Le Brun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |