Late‐Stage Functionalization of Peptides on the Solid Phase
Marius Werner, Truc Lam Pham, Franziska Thomas · 2026
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Description
Marius Werner, Truc Lam Pham, and Franziska Thomas review in 2026 methods for decorating finished peptides while they still sit on their synthesis resin. Peptide drugs often need unusual building blocks added late to tune their action. Working on the resin saves time and money and suits mass screening.
Reactions covered range from simple swaps and carbonyl chemistry to metal-driven and light-driven couplings developed over the past decade. Most handle both short and long peptides, and several demonstrably change biological activity. Libraries built this way in high-throughput formats show the method's reach. The authors expect on-resin tailoring to speed the design of peptide medicines, especially where many variants must be tried quickly.
Catalog record
| CREATOR | Marius Werner, Truc Lam Pham, Franziska Thomas |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62762 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |