A Universal Nucleoside‐to‐Nucleoside‐5′‐Triphosphate Enzyme Cascade Driven by Polyphosphate
Jonathan P Suess, Nicolas V Cornelissen · 2026
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Description
Jonathan Suess and Nicolas Cornelissen present in 2026 a two-enzyme assembly line that builds the energy-carrying building blocks of nucleic acids from simple starting pieces. Making these triphosphate blocks chemically gives poor yields at the last step. A universal green route would serve labs and drug makers alike.
One enzyme, borrowed from fruit flies, takes the first step using a pinch of ATP. The second enzyme, from a gut bacterium, spends cheap polyphosphate to finish the job and recycle the ATP. Only trace amounts of ATP are needed to keep the loop turning. The one-pot system made all standard blocks plus eleven modified ones, including a key ingredient for mRNA medicines at milligram scale.
Catalog record
| CREATOR | Jonathan P Suess, Nicolas V Cornelissen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23410 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |