Time-dependent prognostic value of automated Ki67 assessment and its integration with molecular risk profiling in WHO grade 2 meningioma
Luisa Voßbeck, Felix Ehret, Eilis Perez, Helena Radbruch, Elisabeth G. Hain, Simone Schmid, Julia Onken, Merten Bohn, Nabiha Salman, Leonille Schweizer, David Capper, Moritz Armbrust, David Kaul · 2026
Read Time-dependent prognostic value of automated Ki67 assessment and its integration with molecular risk profiling in WHO grade 2 meningioma by Luisa Voßbeck, Felix Ehret, Eilis Perez, Helena Radbruch, Elisabeth G. Hain, Simone Schmid, Julia Onken, Merten Bohn, Nabiha Salman, Leonille Schweizer, David Capper, Moritz Armbrust, David Kaul (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13411134.txt.
Description
Luisa Voßbeck and colleagues show in 2026 that a growth marker in brain lining tumors predicts recurrence mainly in the first years after surgery. Grade 2 meningiomas vary wildly in behavior, and the standard Ki67 growth count suffers from inconsistent hand scoring. The team paired an automatic counter with molecular risk profiling.
Ninety-eight tumors were scored by software that also discards image artifacts. Automatic values ran far lower than routine hand estimates, which warns against mixing the two. Above a set cutoff, the score strongly predicted local recurrence within about 38 months, then faded. Molecular risk added separate information, so the cheap automatic count may work as a stand-alone watch tool where profiling is unavailable.
Catalog record
| CREATOR | Luisa Voßbeck, Felix Ehret, Eilis Perez, Helena Radbruch, Elisabeth G. Hain, Simone Schmid, Julia Onken, Merten Bohn, Nabiha Salman, Leonille Schweizer, David Capper, Moritz Armbrust, David Kaul |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |